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100 Grams Difelene

Dif-100

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Difelene gel 100 grams against inflammation and rheumatism

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Manufacturer: Difelene

Description:

Difelene Gel relieves pain, reduces swelling due to inflammation. Difelene is a derivative of phenylacetic acid, has a pronounced anti-inflammatory and analgesic effect.

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17,95 €

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Difelene gel 100 grams against inflammation and rheumatism

Incl. Shipping!

Customs and import regulations for Germany

Manufacturer: Difelene

Description:

Difelene Gel relieves pain, reduces swelling due to inflammation. Difelene is a derivative of phenylacetic acid, has a pronounced anti-inflammatory and analgesic effect.

Difelene is an anti-inflammatory and analgesic drug for acute or chronic inflammation of the traumatic or rheumatic origin.

Effect: e.g. against tendonitis, shoulder-arm syndrome, and bursitis. Pain and inflammation caused by disease of the peripheral joints and muscles.

Application:

Depending on the condition of the painful areas, rub in the painful areas 3-4 times a day and massage in.

Ingredients per 100 grams contains:

  • Diclofenac diethyammonium 1.16 g (equivalent to 1.0 g diclofenac sodium)

Difelene Counterpain Rheumatism

Pharmacological action

NSAIDs, a derivative of phenylacetic acid, Diclofenac has a pronounced anti-inflammatory, analgesic and antipyretic mild. The main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play an important role in the development of inflammation, pain and fever - The mechanism of action is associated with an inhibition of COX activity. Analgesic action is based on two mechanisms: peripheral (indirectly via the suppression of prostaglandin synthesis) and centrally (by inhibiting prostaglandin synthesis in the central and peripheral nervous system). Inhibits the synthesis of proteoglycans in cartilage. In rheumatic diseases, diclofenac reduces joint pain at rest and in motion, as well as morning stiffness and swelling of the joints, helps to increase motility, reduces post-traumatic and postoperative pain, and inflammatory edema. Inhibits platelet aggregation. After prolonged use, desensitization has an effect. When used topically in ophthalmology reduces swelling and pain in inflammatory processes of non-infectious etiology.

Pharmacokinetics

After intake is absorbed from the gastrointestinal tract. Eating slows down the rate of absorption, the extent of absorption is not changed. About 50% of the drug is metabolized by the liver in the "first pass". With proper rectal absorption slower. Time to reach Cmax in the plasma after oral administration is 2-4 hours, depending on the dosage form used after rectal - 1 h, IM administration - 20 min. The concentration of active substance in the plasma is a linear function of the applied dose. Not cumulative. Plasma protein binding is 99.7% (predominantly albumin). In joint fluid Cmax is reached in 2-4 hours later than in plasma. Degraded to a great extent to form several metabolites, two of which are pharmacologically active, but to a lesser extent than diclofenac. The systemic clearance of the drug is about 263 ml / min. T1 / 2 from the plasma is 1-2 h, of synovial fluid - 3-6 h. Approximately 60% of the dose as a metabolite through the kidneys, less than 1% in urine as unchanged excretions, while the remainder in the form of bile metabolites.

Why is Difelene prescribed?

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, periartropatii), post-traumatic inflammation of the soft tissues and musculoskeletal system (sprains, bruises). Pain in the spine, neuralgia, muscle pain, joint pain, pain and inflammation after surgery or injury, pain in gout, migraine, algomenorrhea, pain with bursitis, proctitis, colic (bile and kidney), pain in infectious and inflammatory diseases of the ENT organs , For local use: inhibition of miosis during surgery to prevent cataract cystoid macular edema associated with removal and lens implantation, inflammatory eye non-infectious nature, post-traumatic inflammation in penetrating and penetrating wound of the eyeball.

Dosage and application

For oral use for adults single dose is 25-50 mg 2-3 times / 24 h. Frequency of uptake depends on the dosage form used, the severity of the disease and is 1-3 times / 24 h, rectally - 1 time / 24 h, for the treatment of acute diseases or exacerbations of chronic edema use intramuscularly in a dose of 75 mg. For children from 6 years and adolescents daily dose is 2 mg / kg. Topical applied at a dose of 2-4 g (depending on the size of the painful area) on the affected area 3-4 times / 24 h. When used in ophthalmology frequency and duration of application are individual.

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